By Natasha Pomelova, Founder of MedicalSpaLocator.com and melov.ai — 15 years in pharmaceutical commercialization at Takeda, Amgen, Astellas, and Horizon Therapeutics.
Semaglutide and tirzepatide are the two leading GLP-1 weight-loss medications. They're related but not identical, and the right choice depends on cost, results, and how you tolerate them.
How they differ
Semaglutide (Ozempic/Wegovy) targets one hormone pathway (GLP-1); tirzepatide (Mounjaro/Zepbound) targets two (GLP-1 and GIP). In head-to-head data, tirzepatide tends to produce greater average weight loss, though both are effective. Learn about semaglutide and tirzepatide.
Cost comparison
Medically supervised programs for either typically run $300–$700 per month. Tirzepatide is sometimes priced higher. Compounded versions of each may cost less from a licensed pharmacy — verify legitimacy before choosing on price.
Both medications can cause nausea during dose escalation — a supervising clinician starts low and increases gradually to minimize side effects.
Which is right for you?
The best choice depends on your health history, tolerance for side effects (both can cause nausea during dose escalation), and provider guidance. A supervising clinician will recommend the right starting point and adjust over time.
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