The Short Answer: Both Work, But They’re Not Identical
Botox (onabotulinumtoxinA) and Dysport (abobotulinumtoxinA) are both FDA-approved neurotoxins that relax muscles to smooth wrinkles. The key differences: Dysport kicks in faster (2–3 days vs. 5–7 for Botox), spreads more (better for large areas like the forehead), and typically costs 10–20% less per treatment area. Botox is more precise for small, targeted areas. According to RealSelf, Botox has a 97% Worth It rating, while Dysport has a 95% Worth It rating.
Head-to-Head Comparison
| Factor | Botox | Dysport |
|---|---|---|
| Active Ingredient | OnabotulinumtoxinA | AbobotulinumtoxinA |
| FDA Approved | 2002 (cosmetic) | 2009 (cosmetic) |
| Onset | 5–7 days | 2–3 days |
| Duration | 3–4 months | 3–4 months |
| Spread | Minimal (precise) | More diffusion (wider) |
| Cost/Unit | $10–$20 | $4–$8 |
| Units Needed (Forehead) | 10–30 units | 25–75 units |
| Cost Per Area | $200–$500 | $175–$425 |
| Best For | Crow’s feet, precise areas | Forehead, large surface areas |
| RealSelf Rating | 97% Worth It | 95% Worth It |
Key insight: Dysport uses ~2.5–3x more units than Botox for the same area, but each unit costs less. The total per-area cost is typically 10–20% lower for Dysport.
When to Choose Botox
- Small, precise areas: Crow’s feet, bunny lines, lip flip—where you want minimal spread
- First-time patients: Botox has a longer track record (FDA approved since 2002) and more provider experience
- Fine-tuning: When you need precise control over exactly which muscles relax
- If Dysport didn’t work for you: Some patients respond better to one formulation over the other
When to Choose Dysport
- Large surface areas: Forehead lines benefit from Dysport’s natural spread
- Need results fast: Dysport’s 2–3 day onset is ideal before events
- Budget-conscious: Dysport costs 10–20% less per treatment area on average
- Natural look preference: The wider diffusion can create a softer, less “frozen” appearance
Can You Switch Between Botox and Dysport?
Yes. You can switch between Botox and Dysport at any time. Wait until your current treatment wears off (3–4 months), then try the other. Many patients experiment to find which they prefer. Your provider can help determine the equivalent dosing.
Frequently Asked Questions
Is Dysport cheaper than Botox?
Per unit, yes—Dysport costs $4–$8/unit vs. Botox at $10–$20/unit. But Dysport requires 2.5–3x more units. The total cost per treatment area is typically 10–20% less for Dysport.
Which lasts longer, Botox or Dysport?
Both last 3–4 months on average. Some patients report Dysport wearing off slightly faster, but clinical studies show comparable duration. Individual metabolism plays a bigger role than the product itself.
Does Dysport look more natural than Botox?
Dysport’s wider spread can create a softer, more natural look on large areas like the forehead. However, this same spread makes it less ideal for precise areas like crow’s feet where Botox’s precision is preferred.
Can I mix Botox and Dysport in the same session?
It’s not recommended to mix neurotoxin brands in the same session. However, you can use Botox on precise areas (crow’s feet) and Dysport on broader areas (forehead) at different appointments.
Which should I choose for my first time?
Most first-time patients start with Botox due to its longer track record and wider provider familiarity. If budget is a concern or you need fast results, discuss Dysport with your provider.
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Related: why Botox can fade faster, plus regenerative alternatives.